Zoloft (sertraline) is a drug used for treating depression, Sitagliptin metformin anxiety and Sitagliptin metformin obsessive compulsive disorder. Launched in 1992 it has since been used in over 10.2 billion patient days of therapy. In clinical trials, 50% of patients taking sertraline showed signs of improvement as opposed to a typical placebo response of 32% (mulrow).