Ian nerve at the wrist as described earlier [4]. Results were classified as bilateral absent N20 or at least unilateral present. The majority of SSEPs were performed between 48 and 96 hours after cardiac arrest. In 62 out of 98 patients, all three parameters (GWR, NSE and SSEP) were available. In this patient cohort, we determined sensitivity and specificity for poor outcome prediction for all three parameters separately as well as for the combination of SSEP and NSE (predicting poor outcome if both NSE > 97 g/L and bilateral absent N20) and for the combination of SSEP, Staurosporine NSE and GWR (predicting poor outcome by at least two of three parameters, NSE > 97 g/L, bilateral absent N20, GWR PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/15501003 regions (CN, PU, THL, MC1, MC2) were significantly lower in patients with poor outcome. In contrast, the absolute attenuation in white matter regions (CC, PIC, MWM1, MWM2) revealed no significant difference (Table 2). ROC analysis demonstrated an area under the curve (AUC) for GWR-AV = 0.81, GWR-BG = 0.77 and GWRCE = 0.75 (Additional file 1: Figure S1). Therefore we used GWR-AV for all subsequent analysis and refer to it as GWR in the following. GWR 97 g/L, 55 by bilaterally absent SSEP and 35 by GWR 97 g/L or GWR 97 g/L and 70 of patients (28/40) with poor outcome had at least one of three parameters (SSEP, NSE, GWR) suggesting poor.